201

时磊 研究员



时磊(Lei Shi)

Professor

Dalian Institute of Chemical Physics, 
Chinese Academy of Sciences, 
457 Zhongshan Road, Dalian 116023, P. R. China

Tel: 86-411-84379325 (office)
E-mail: 
shileichem@dicp.ac.cn

 

Educational and Professional Background:

2001.9-2007.4, Ph. D.  in Applied Chemistry, Advisor Prof. Xiaobing Lu, Dalian University of Technology, Dalian, China. 
Dissertation:  Asymmetric Copolymerization of Carbon Dioxide and Epoxide

1997.9-2001.7, B.S. in Fine Chemicals,  Dalian University of Technology, Dalian, China.

 

Awards:

National  Exellent Doctoral Dissertation Nominee (2009, China)
Fellowship of the  Alexander von Humboldt Foundation (2008, Germany) 

Excellent Doctoral  Dissertation of Liaoning Province (2008, Liaoning    Province, China) 
Excellent Doctoral  Dissertation of Dalian   University of Technology  (2007, DLUT)
Hou yufen Award for excellent PhD graduates (2007,  DLUT)

 
 
Representative Publications:
       

34. Xiao-Yong Zhai, Shu-Bo Hu, Lei Shi  and Yong-Gui Zhou.* Synthesis of Poly(silyl ethers) via Iridium-Catalyzed  Dehydrocoupling Polymerization. Organometallics 2018, 37, 2342-2347.


                         
                                               


       
33. Guang-Shou Feng, Mu-Wang Chen, Lei Shi* and Yong-Gui Zhou.* Facile Synthesis of Chiral Cyclic Ureas through Hydrogenation of  2-Hydroxypyrimidine/Pyrimidin-2(1H)-one Tautomers. Angew. Chem. Int. Ed. 2018, 57, 5853-5857.



                         
                                               


                                           

       
32. Yue Ji, Jie Wang, Mu-Wang Chen, Lei Shi* and Yong-Gui Zhou.* Dual Stereocontrol for Enantio- selective Hydrogenation of Dihydroisoquinolines Induced by Tuning the Amount of N-Bromosuccinimide. Chin. J. Chem. 2018, 36, 139-142.



                         
                                               



       
31. Mu-Wang Chen, Yue Ji, Jie Wang, Qing-An Chen, Lei Shi and Yong-Gui Zhou.* Asymmetric  Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in situ as Activator. Org. Lett. 2017, 19, 4988-4991.



                         
                                               


       
30. Yue Ji, Guang-Shou Feng,  Mu-Wang Chen, Lei Shi,* Haifeng Du and Yong-Gui Zhou.* Iridium-catalyzed Asymmetric Hydrogenation of Cyclic Iminium Salts. Org. Chem. Front. 2017, 4, 1125-1129.



                         
                                               



                     

       
29. Mu-Wang Chen, Bo Wu, Zhang-Pei Chen, Lei Shi and Yong-Gui Zhou.* Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation. Org. Lett. 2016, 18, 4650-4653.



                       
                                                   
                     



       
28. Guang-Shou Feng, Yue Ji, Hui-Fang Liu, Lei Shi* and Yong-Gui Zhou.* Solvent-promoted Highly Selective Dehydrogenation of Tetrahydroisoquinolines without Catalyst and Hydrogen Acceptor. Tetrahedron Letters 2016, 57, 747–749.




                                                 
                     



       

27. Yue Ji, Lei Shi,* Mu-Wang Chen, Guang-Shou Feng, and Yong-Gui Zhou.* Concise Redox De- racemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process. J. Am. Chem. Soc. 2015, 137, 10496-10499.



                       
                       
                     



       

26. Zhang-Pei             Chen,                                      Mu-Wang             Chen, Lei             Shi,                                      Chang-Bin             Yu and Yong-Gui Zhou.* Pd-catalyzed Asy- mmetric Hydrogenation of Fluorinated Aromatic Pyrazol-5-ols via Capture of Active Tautomers. Chem. Sci. 2015, 6, 3415-3419.



                                               
                     


       

25. Yue Ji, Mu-Wang Chen, Lei Shi* and Yong-Gui Zhou.* Highly selective partial dehydrogenation of tetrahydroisoquinolines using modified Pd/C. Chin. J. Catal. 2015, 36, 33-39.




                                                 
                     

       

24. Lei Shi* and Yong-Gui Zhou.* Enantioselective Metal-Free Hydrogenation Catalyzed by
                           Chiral Frustrated Lewis Pairs. ChemCatChem. 2015, 7, 54–56.




                                                 
                     

       

23. Chang-Bin Yu,                            Wen-Xue Huang, Lei Shi, Mu-Wang Chen, Bo Wu, and Yong-Gui Zhou.* Asymmetric Hydrogenation via Capture of Active Intermediates Generated from Aza-Pinacol Rearrangement. J. Am. Chem. Soc. 2014, 136, 15837-15840.




                                                 
                     

       
22. Mu-Wang Chen, Xian-Feng Cai, Zhang-Pei Chen, Lei Shi and Yong-Gui Zhou.* Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines. Chem. Commun. 2014, 50, 12526-12529.




                                                 
                     


       
21. Lei Shi,* Yue Ji, Wen-Xue Huang and Yong-Gui Zhou.* Application of Chiral Anion Metathesis Strategy in Asymmetric Transfer Hydrogenation of Isoquinolines. Acta Chim. Sinica 2014,72, 820-824.




                                                 
                     


       
20.     Wen-Xue Huang, Chang-Bin Yu, Lei Shi and Yong-Gui Zhou.* Iridium-Catalyzed Asymmetric Hydrogenation of Pyrrolo[1,2-a]pyrazinium Salts. Org. Lett. 2014, 16, 3324-3327.


    

 


       
19. Ran-Ning  Guo, Xian-Feng Cai,  Lei Shi,* Zhang-Pei Chen and Yong-Gui  Zhou.* Synthesis of Fluorinated Heteroaromatics via Formal Substitution of Nitro  Group by Fluorine under Transition Metal-Free Condition. Chem. Eur. J. 2014, 20, 8343-8346.




                                                      


       
18. Xian-Feng Cai,  Ran-Ning  Guo, Mu-Wang Chen, Lei Shi and Yong-Gui  Zhou.* Synthesis of  Chiral Exocyclic Amines via Asymmetric Hydrogenation of Aromatic Quinolin-3-amines. Chem. Eur. J. 2014, 20, 7245-7248.




                                                        
                       

       
17.  Zhi-Shi Ye, Lei Shi* and Yong-Gui Zhou. Asymmetric Hydrogenation of Aromatic Carbocyclic Rings and Thiophenes. Synlett 2014, 25, 0928-0931.



 
                                                       
                       


       
16. Ran-Ning Guo, Xian-Feng Cai, Lei Shi, Zhi-Shi Ye, Mu-Wang Chen and Yong-Gui Zhou.* An Efficient Route to Chiral N-Heterocycles Bearing C-F Stereogenic Center via Asymmetric Hydrogenation of Fluorinated Isoquinolines. Chem. Commun. 2013, 49, 8537-8539.



                       

       
15. Xian-Feng Cai, Mu-Wang  Chen, Zhi-Shi  Ye, Ran-Ning  Guo, Lei Shi, Yan-Qin  Li and Yong-Gui  Zhou.* Asymmetric Transfer  Hydrogenation of Aromatic Nitro Compounds, 3-Nitroquinolines: A Facile Access  to Cyclic Nitro Compounds with Two Contiguous Stereocenters. Chem. Asian J. 2013, 8, 1381-1385.




                       

 

       

14. Zhi-Shi Ye, Ran-Ning Guo, Xian-Feng Cai, Mu-Wang Chen, Lei Shi and Yong-Gui Zhou.* Enantioselective Iridium-Catalyzed Hydrogenation of 1- and 3-Substituted Isoquinolinium Salts. Angew. Chem. Int. Ed. 2013 , 52, 3685-3689.

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13.                       Hong-Qiang Liu,  Lei Shi, Qing-An Chen, Lei Wang* and Yong-Gui Zhou.* Synthesis of MeO-PEG-Supported Ferrocenyloxazoline Ligands and                            Their Application in Asymmetric Catalysis. Acta Chim. Sinica 2013, 71, 40-43.



                     


       
12.  Ran-Ning  Guo, Kai Gao, Zhi-Shi Ye, Lei Shi,  Yanqin Li and Yong-Gui Zhou.* Iridium-Catalyzed Asymmetric Hydrogenation of  Dibenzo[b,f][1,4]thiazepines. Pure Appl. Chem. 2013, 85, 843-849.

 

       
11. Zhi-Shi Ye, Mu-Wang Chen, Qing-An Chen, Lei Shi, Ying  Duan and Yong-Gui Zhou.* Ir-Catalyzed Asymmetric  Hydrogenation of Pyridinium Salts. Angew. Chem. Int. Ed. 2012, 51, 10181-10184.

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10. Lei Shi, Zhi-Shi Ye, Liang-Liang Cao, Ran-Ning Guo, Yue Hu and Yong-Gui Zhou.* Enantioselective Iridium-Catalyzed Hydrogenation of 3,4-Disubstituted   Isoquinolines. Angew. Chem. Int. Ed. 2012, 51, 8286-8289.
                             
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9.Qing-An Chen, Kai Gao, Ying Duan, Zhi-Shi Ye, Lei Shi, Yan  Yang and Yong-Gui Zhou.* Dihydrophenanthridine: A New and Easily Regenerable NAD(P)H Model for Biomimetic Asymmetric Hydrogenation. J.                              Am. Chem. Soc. 2012, 134,  2442-2448.
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8. Qing-An Chen, Mu-Wang Chen, Chang-Bin Yu, Lei Shi, Duo-Sheng Wang, Yan  Yang and Yong-Gui Zhou.*   Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters  for Asymmetric Hydrogenation of Benzoxazinones. J.                            Am. Chem. Soc. 2011, 133, 16432-16435.
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7. Chang-Bin Yu, Kao Gao, Duo-Sheng Wang, Lei Shi and Yong-Gui Zhou.*  Enantioselective Pd-catalyzed hydrogenation of  enesulfonamides. Chem. Commun. 2011, 47, 5052-5054.
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6. Gansauer,  A.;* Otte, M.; Shi, L. Radical Cyclizations  Terminated by Ir-Catalyzed Hydrogen Atom Transfer. J.  Am. Chem. Soc. 2011, 133, 416-417.

 

 

   
5. Gansauer,  A.;* Shi, L.; Otte, M. Catalytic Enantioselective Radical Cyclization  via Regiodivergent Epoxide Opening. J.  Am. Chem. Soc. 2010, 132, 11858-11859.

 

   
4. Gansauer,  A.;* Shi, L.; Keller, F.; Karbaum, P.; Fan, C.-A.* Regiodivergent epoxide  opening (REO) via electron transfer: Control Elements. Tetrahedron:  Asymmetry 2010, 21, 1361-1369.

 

   
3. Dai,  W.-M.;* Shi, L.; Li, Y.-N. Total Synthesis of (4S, 10R)-4-Hydroxy-10-methyl-11-  oxododec-2-en-1, 4-olide and Related Bioactive Marine Butenolides. Tetrahedron: Asymmetry 2008, 19, 1549–1556.

 

   
2. Lu, X.-B.;* Shi, L.;  Wang, Y.-M.; Zhang, R.; Zhang, Y.; Peng, X.-J.; Zhang, Z.-C.; Li, B. Design of  Highly Active Binary Catalyst Systems for CO2/Epoxide  Copolymerization: Polymer Selectivity, Enantioselectivity, and Stereochemistry  Control. J. Am. Chem. Soc. 2006, 128, 1664-1674.

 

   
1. Shi, L.;  Lu, X.-B.;* Zhang, R.; Peng, X.-J.;* Zhang, C.-Q.; Li, J.-F.; Peng, X.-M.  Asymmetric Alternating Copolymerization  and Ter-polymerzation of Epoxide with Carbon Dioxide at Mild Condition. Macromolecules 2006, 39, 5679-5685.