时磊(Lei Shi),课题组副组长

Professor

Dalian Institute of Chemical Physics,
Chinese Academy of Sciences,
457 Zhongshan Road, Dalian 116023, P. R. China

Tel: 86-411-84379325 (office)
E-mail:
shileichem@dicp.ac.cn

 

Scientific Appointment

2008.3– 2010.6 Fellowship of the Alexander von Humboldt Foundation, Bonn University, Bonn, Germany, Host: Prof. Dr. Andreas Gansauer

2007.2– 2008.2 Research Associate in Department of Chemistry, Hongkong University of Science and Technology, Hongkong, China, Supervisor: Prof. Dr. Weimin Dai

 

Educational Background

2001.9-2007.4, Ph. D. in Applied Chemistry, Advisor Prof. Xiaobing Lu, Dalian University of Technology, Dalian, China.
Dissertation: Asymmetric Copolymerization of Carbon Dioxide and Epoxide

1997.9-2001.7, B.S. in Fine Chemicals, Dalian University of Technology, Dalian, China.

 

Awards:

 

National Exellent Doctoral Dissertation Nominee (2009, China)
Fellowship of the Alexander von Humboldt Foundation (2008, Germany)
Excellent Doctoral Dissertation of Liaoning Province (2008, Liaoning Province, China)
Excellent Doctoral Dissertation of Dalian University of Technology (2007, DLUT)
Hou yufen Award for excellent PhD graduates (2007, DLUT)

 
Representative Publications:
 
31. Mu-Wang Chen, Yue Ji, Jie Wang, Qing-An Chen, Lei Shi and Yong-Gui Zhou.* Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in situ as Activator. Org. Lett. 2017, 19, 4988-4991.




30. Yue Ji, Guang-Shou Feng, Mu-Wang Chen, Lei Shi,* Haifeng Du and Yong-Gui Zhou.* Iridium-catalyzed Asymmetric Hydrogenation of Cyclic Iminium Salts. Org. Chem. Front. 2017, 4, 1125-1129.




29. Mu-Wang Chen, Bo Wu, Zhang-Pei Chen, Lei Shi and Yong-Gui Zhou.* Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation. Org. Lett. 2016, 18, 4650-4653.




28. Guang-Shou Feng, Yue Ji, Hui-Fang Liu, Lei Shi* and Yong-Gui Zhou.* Solvent-promoted Highly Selective Dehydrogenation of Tetrahydroisoquinolines without Catalyst and Hydrogen Acceptor. Tetrahedron Letters 2016, 57, 747–749.



27. Yue Ji, Lei Shi,* Mu-Wang Chen, Guang-Shou Feng, and Yong-Gui Zhou.* Concise Redox De- racemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process. J. Am. Chem. Soc. 2015, 137, 10496-10499.



26. Zhang-Pei Chen, Mu-Wang Chen, Lei Shi, Chang-Bin Yu and Yong-Gui Zhou.* Pd-catalyzed Asy- mmetric Hydrogenation of Fluorinated Aromatic Pyrazol-5-ols via Capture of Active Tautomers. Chem. Sci. 2015, 6, 3415-3419.



25. Yue Ji, Mu-Wang Chen, Lei Shi* and Yong-Gui Zhou.* Highly selective partial dehydrogenation of tetrahydroisoquinolines using modified Pd/C. Chin. J. Catal. 2015, 36, 33-39.



24. Lei Shi* and Yong-Gui Zhou.* Enantioselective Metal-Free Hydrogenation Catalyzed by
Chiral Frustrated Lewis Pairs. ChemCatChem. 2015, 7, 54–56.



23. Chang-Bin Yu, Wen-Xue Huang, Lei Shi, Mu-Wang Chen, Bo Wu, and Yong-Gui Zhou.* Asymmetric Hydrogenation via Capture of Active Intermediates Generated from Aza-Pinacol Rearrangement. J. Am. Chem. Soc. 2014, 136, 15837-15840.



22. Mu-Wang Chen, Xian-Feng Cai, Zhang-Pei Chen, Lei Shi and Yong-Gui Zhou.* Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines. Chem. Commun. 2014, 50, 12526-12529.



21. Lei Shi,* Yue Ji, Wen-Xue Huang and Yong-Gui Zhou.* Application of Chiral Anion Metathesis Strategy in Asymmetric Transfer Hydrogenation of Isoquinolines. Acta Chim. Sinica 2014,72, 820-824.



20. Wen-Xue Huang, Chang-Bin Yu, Lei Shi and Yong-Gui Zhou.* Iridium-Catalyzed Asymmetric Hydrogenation of Pyrrolo[1,2-a]pyrazinium Salts. Org. Lett. 2014, 16, 3324-3327.

    

 

19. Ran-Ning Guo, Xian-Feng Cai, Lei Shi,* Zhang-Pei Chen and Yong-Gui Zhou.* Synthesis of Fluorinated Heteroaromatics via Formal Substitution of Nitro Group by Fluorine under Transition Metal-Free Condition. Chem. Eur. J. 2014, 20, 8343-8346.


     

18. Xian-Feng Cai, Ran-Ning Guo, Mu-Wang Chen, Lei Shi and Yong-Gui Zhou.* Synthesis of Chiral Exocyclic Amines via Asymmetric Hydrogenation of Aromatic Quinolin-3-amines. Chem. Eur. J. 2014, 20, 7245-7248.


     
17. Zhi-Shi Ye, Lei Shi* and Yong-Gui Zhou. Asymmetric Hydrogenation of Aromatic Carbocyclic Rings and Thiophenes. Synlett 2014, 25, 0928-0931.

 
    

16. Ran-Ning Guo, Xian-Feng Cai, Lei Shi, Zhi-Shi Ye, Mu-Wang Chen and Yong-Gui Zhou.* An Efficient Route to Chiral N-Heterocycles Bearing C-F Stereogenic Center via Asymmetric Hydrogenation of Fluorinated Isoquinolines. Chem. Commun. 2013, 49, 8537-8539.

15. Xian-Feng Cai, Mu-Wang Chen, Zhi-Shi Ye, Ran-Ning Guo, Lei Shi, Yan-Qin Li and Yong-Gui Zhou.* Asymmetric Transfer Hydrogenation of Aromatic Nitro Compounds, 3-Nitroquinolines: A Facile Access to Cyclic Nitro Compounds with Two Contiguous Stereocenters. Chem. Asian J. 2013, 8, 1381-1385.


 

14. Zhi-Shi Ye, Ran-Ning Guo, Xian-Feng Cai, Mu-Wang Chen, Lei Shi and Yong-Gui Zhou.* Enantioselective Iridium-Catalyzed Hydrogenation of 1- and 3-Substituted Isoquinolinium Salts. Angew. Chem. Int. Ed. 2013 , 52, 3685-3689.

<Highlighted by Angew. Chem. Int. Ed. 2013, 52, 9616 >

 

 

13. Hong-Qiang Liu, Lei Shi, Qing-An Chen, Lei Wang* and Yong-Gui Zhou.* Synthesis of MeO-PEG-Supported Ferrocenyloxazoline Ligands and Their Application in Asymmetric Catalysis. Acta Chim. Sinica 2013, 71, 40-43.


12. Ran-Ning Guo, Kai Gao, Zhi-Shi Ye, Lei Shi, Yanqin Li and Yong-Gui Zhou.* Iridium-Catalyzed Asymmetric Hydrogenation of Dibenzo[b,f][1,4]thiazepines. Pure Appl. Chem. 2013, 85, 843-849.

 

11. Zhi-Shi Ye, Mu-Wang Chen, Qing-An Chen, Lei Shi, Ying Duan and Yong-Gui Zhou.* Ir-Catalyzed Asymmetric Hydrogenation of Pyridinium Salts. Angew. Chem. Int. Ed. 2012, 51, 10181-10184.

<Highlighted by Angew. Chem. Int. Ed. 2013, 52, 9616 >

 

 

10. Lei Shi, Zhi-Shi Ye, Liang-Liang Cao, Ran-Ning Guo, Yue Hu and Yong-Gui Zhou.* Enantioselective Iridium-Catalyzed Hydrogenation of 3,4-Disubstituted Isoquinolines. Angew. Chem. Int. Ed. 2012, 51, 8286-8289.
<Highlighted by Synfacts 2012, 1226 >

<Highlighted by Angew. Chem. Int. Ed. 2013, 52, 9616 >

 

 

9.Qing-An Chen, Kai Gao, Ying Duan, Zhi-Shi Ye, Lei Shi, Yan Yang and Yong-Gui Zhou.* Dihydrophenanthridine: A New and Easily Regenerable NAD(P)H Model for Biomimetic Asymmetric Hydrogenation. J. Am. Chem. Soc. 2012, 134, 2442-2448.
<Highlighted by Synlett 2012, 1300 >
<Highlighted by Angew Chem. Int. Ed. 2012, 51, 11423-11425 >

 

8. Qing-An Chen, Mu-Wang Chen, Chang-Bin Yu, Lei Shi, Duo-Sheng Wang, Yan Yang and Yong-Gui Zhou.* Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters for Asymmetric Hydrogenation of Benzoxazinones. J. Am. Chem. Soc. 2011, 133, 16432-16435.
<Highlighted by Synlett 2012, 1300 >

 

 

7. Chang-Bin Yu, Kao Gao, Duo-Sheng Wang, Lei Shi and Yong-Gui Zhou.* Enantioselective Pd-catalyzed hydrogenation of enesulfonamides. Chem. Commun. 2011, 47, 5052-5054.
<Highlighted by SYNFACTS 2011, 868 >

 

6. Gansauer, A.;* Otte, M.; Shi, L. Radical Cyclizations Terminated by Ir-Catalyzed Hydrogen Atom Transfer. J. Am. Chem. Soc. 2011, 133, 416-417.

 

 

5. Gansauer, A.;* Shi, L.; Otte, M. Catalytic Enantioselective Radical Cyclization via Regiodivergent Epoxide Opening. J. Am. Chem. Soc. 2010, 132, 11858-11859.

 

4. Gansauer, A.;* Shi, L.; Keller, F.; Karbaum, P.; Fan, C.-A.* Regiodivergent epoxide opening (REO) via electron transfer: Control Elements. Tetrahedron: Asymmetry 2010, 21, 1361-1369.

 

3. Dai, W.-M.;* Shi, L.; Li, Y.-N. Total Synthesis of (4S, 10R)-4-Hydroxy-10-methyl-11- oxododec-2-en-1, 4-olide and Related Bioactive Marine Butenolides. Tetrahedron: Asymmetry 2008, 19, 1549–1556.

 

2. Lu, X.-B.;* Shi, L.; Wang, Y.-M.; Zhang, R.; Zhang, Y.; Peng, X.-J.; Zhang, Z.-C.; Li, B. Design of Highly Active Binary Catalyst Systems for CO2/Epoxide Copolymerization: Polymer Selectivity, Enantioselectivity, and Stereochemistry Control. J. Am. Chem. Soc. 2006, 128, 1664-1674.

 

1. Shi, L.; Lu, X.-B.;* Zhang, R.; Peng, X.-J.;* Zhang, C.-Q.; Li, J.-F.; Peng, X.-M. Asymmetric Alternating Copolymerization and Ter-polymerzation of Epoxide with Carbon Dioxide at Mild Condition. Macromolecules 2006, 39, 5679-5685.

 



 

 

 

 

 

 
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