Mu-Wang Chen(陈木旺)

Associate Professor

Dalian Institute of Chemical Physics,
Chinese Academy of Sciences,
457 Zhongshan Road, Dalian 116023, P. R. China
Tel: 86-411-84379325 (office)



Educational and Professional Background:

2009.7- present, Assistant Research Fellow, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China.
2006.9-2009.7, M.S. in Chemistry, University of Wenzhou.



Representative Publications:

44. Cong Liu, Hong-Qiang Shen, Mu-Wang Chen  and Yong-Gui Zhou.* C2-Symmetric Hindered “Sandwich” Chiral N-Heterocyclic Carbene  Precursors and Their Transition Metal Complexes: Expedient  Syntheses, Structural Authentication, and Catalytic Properties. Organometallics 2018, 37, 3756-3769.



43. Guang-Shou Feng, Lei Shi,* Fan-Jie Meng, Mu-Wang Chen and Yong-Gui Zhou.* Iridium-Catalyzed Asymmetric Hydrogenation of 4,6-Disubstituted 2-Hydroxypyrimidines. Org. Lett. 2018, 20, 6415-6419.


42. Guang-Shou Feng, Mu-Wang Chen, Lei Shi*  and Yong-Gui Zhou.* Facile Synthesis of Chiral Cyclic Ureas through Hydrogenation of  2-Hydroxypyrimidine/Pyrimidin-2(1H)-one Tautomers. Angew. Chem. Int. Ed. 2018, 57, 5853-5857.


41. Bo Song, Mu-Wang Chen and Yong-Gui Zhou.* Synthesis of Chiral Sultams  with Two Adjacent Stereocenters via Palladium-catalyzed Dynamic Kinetic  Resolution. Org. Chem. Front. 2018, 5, 1113-1117.

40. Shu-Bo Hu, Mu-Wang Chen, Xiao-Yong Zhai and Yong-Gui Zhou.* Synthesis of Tetrahydropyrrolo/ indolo[1,2-a]pyrazines by Enantioselective Hydrogenation of Heterocyclic Imines. Acta Chim. Sinica 2018, 76, 103-106.


39. Yue Ji, Jie Wang, Mu-Wang Chen, Lei Shi* and Yong-Gui Zhou.* Dual Stereocontrol for Enantioselective Hydrogenation of Dihydroisoquinolines Induced by Tuning the Amount of N-Bromosuccinimide. Chin. J. Chem. 2018, 36, 139-142.


38. Mu-Wang Chen, Yue Ji,  Jie Wang, Qing-An Chen, Lei Shi and Yong-Gui Zhou.* Asymmetric  Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in situ as Activator. Org. Lett. 2017, 19, 4988-4991.


37. Yue Ji, Guang-Shou Feng, Mu-Wang Chen,  Lei Shi, Haifeng Du and Yong-Gui Zhou.* Iridium-catalyzed Asymmetric Hydrogenation of Cyclic Iminium Salts. Org. Chem. Front. 2017, 4, 1125-1129.


36. Bo Song, Chang-Bin Yu,  Yue Ji, Mu-Wang Chen and Yong-Gui Zhou.* Synthesis of Chiral Sultams via Palladiumcatalyzed Intramolecular Asymmetric Reductive Amination. Chem. Commun. 2017, 53, 1704-1707.


35. Mu-Wang Chen, Bo Wu,  Zhang-Pei Chen, Lei Shi and Yong-Gui Zhou.* Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation. Org. Lett. 2016, 18, 4650-4653.


34. Jie Wang, Mu-Wang Chen, Yue Ji, Shu-Bo Hu  and Yong-Gui Zhou.* Kinetic Resolution of Axially Chiral 5- or 8-Substituted Quinolines via Asymmetric Transfer Hydrogenation. J. Am. Chem. Soc. 2016, 138, 10413-10416.


33. Zhang-Pei Chen, Shu-Bo Hu, Mu-Wang Chen and  Yong-Gui Zhou.* Synthesis of Chiral Fluorinated Hydrazines via Pd-Catalyzed Asymmetric Hydrogenation. Org. Lett. 2016, 18, 2676-2679.


32. Zhong Yan, Bo Wu, Xiang Gao,  Mu-Wang Chen and Yong-Gui Zhou.* Enantioselective Synthesis of α-Amino Phosphonates  via Pd-Catalyzed Asymmetric Hydrogenation.  Org. Lett. 2016, 18, 692–695.    


31. Bo Wu, Xiang Gao, Zhong Yan, Mu-Wang Chen, and Yong-Gui Zhou.* C-H Oxidation/Michael Addition/Cyclization Cascade for Enantioselective Synthesis of Functionalized 2-Amino-4 H-chromenes. Org. Lett201517, 6134-6137.  



30. Xiang Gao, Bo Wu, Wen-Xue Huang, Mu-Wang Chen, and Yong-Gui Zhou.* Enantioselective Palladium-Catalyzed C-H Functionalization of Indoles Using an Axially Chiral 2,2’-Bipyridine Ligand. Angew. Chem. Int. Ed. 2015, 54, 11956-11960.



29. Yue Ji, Lei Shi,* Mu-Wang Chen, Guang-Shou Feng, and Yong-Gui Zhou.* Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process. J. Am. Chem. Soc. 2015, 137, 10496-10499.



28. Zhang-Pei Chen, Mu-Wang Chen,  Lei Shi,  Chang-Bin Yu and Yong-Gui Zhou.* Pd-catalyzed Asymmetric Hydrogenation of Fluorinated Aromatic Pyrazol-5-ols via Capture of Active Tautomers. Chem. Sci. 2015, 6, 3415-3419.



27.  Mu-Wang Chen, Zhi-Shi Ye, Zhang-Pei Chen, Bo Wu and Yong-Gui Zhou.* Enantioselective Synthesis of Trifluoromethyl  Substituted Piperidines with Multiple Stereogenic Centers via Hydrogenation of Pyridinium Hydrochlorides. Org. Chem. Front. 2015, 2, 586-589.



26. Wen-Xue Huang, Bo Wu, Xiang Gao, Mu-Wang Chen, Baomin Wang* and Yong-Gui Zhou.* Iridium-Catalyzed Selective Hydrogenation of 3-Hydroxypyridinium Salts: A Facile Synthesis of Piperidin-3-ones. Org. Lett. 2015, 17, 1640-1643.



25. Bo Wu, Xiang Gao, Mu-Wang Chen and Yong-Gui Zhou.* Direct amination of 2-(1-tosylalkyl) phenols with aqueous ammonia: a metal-free synthesis of primary amines. Tetrahedron Lett. 2015, 56, 1135–1137.



24. Yue Ji, Mu-Wang Chen, Lei Shi* and Yong-Gui Zhou.* Highly selective partial dehydrogenation of tetrahydroisoquinolines using modified Pd/C. Chin. J. Catal. 2015, 36, 33-39.



23. Bo Song, Chang-Bin Yu, Wen-Xue Huang, Mu-Wang Chen,  and Yong-Gui Zhou.* Formal Palladium-Catalyzed Asymmetric Hydrogenolysis of Racemic N-Sulfonyloxaziridines. Org. Lett. 2015, 17, 190-193.



22. Chang-Bin Yu, Wen-Xue Huang, Lei Shi, Mu-Wang Chen, Bo Wu, and Yong-Gui Zhou.* Asymmetric Hydrogenation via Capture of Active Intermediates Generated from Aza-Pinacol Rearrangement. J. Am. Chem. Soc. 2014, 136, 15837-15840.



21. Bo Wu, Xiang Gao, Mu-Wang Chen, and Yong-Gui Zhou.* A Concise Synthesis of 2-(2-Hydroxy-phenyl)acetonitriles via the o-Quinone Methides Generated from 2-(1-Tosylalkyl)phenols. Chin. J. Chem. 2014, 32, 981-984.

< Cover Article 2014, 32, 10 >


20. Mu-Wang Chen, Xian-Feng Cai, Zhang-Pei Chen, Lei Shi and Yong-Gui Zhou.* Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines. Chem. Commun. 2014, 50, 12526-12529.


19. Ying Duan, Lu Li, Mu-Wang Chen, Chang-Bin Yu, Hong-Jun Fan* and Yong-Gui Zhou.* Homogenous Pd-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles: Scope and Mechanistic Studies. J. Am. Chem. Soc. 2014, 136, 7688-7700.


18. Jing Luo, Bo Wu, Mu-Wang Chen, Guo-Fang Jiang*  and Yong-Gui  Zhou.* The Concise Synthesis of Spiro-Cyclopropane Compounds via the Dearomatization  of Indole Derivatives. Org. Lett. 2014, 16, 2578-2581.


17. Xian-Feng Cai, Ran-Ning Guo, Mu-Wang Chen, Lei Shi and Yong-Gui Zhou.* Synthesis of  Chiral Exocyclic Amines via Asymmetric Hydrogenation of Aromatic Quinolin-3-amines. Chem. Eur. J. 2014, 20, 7245-7248.


16. Zhang-Pei Chen, Mu-Wang Chen, Ran-Ning Guo and Yong-Gui Zhou.* 4,5-Dihydropyrrolo[1,2-a] quinoxalines: A Tunable and Regenerable Biomimetic Hydrogen Source. Org. Lett. 2014, 16, 1406–1409.


15. Bo Wu, Mu-Wang Chen, Zhi-Shi Ye, Chang-Bin Yu and Yong-Gui Zhou.* A Streamlined Synthesis of 2,3-Dihydrobenzofurans via the ortho-Quinone Methides Generated from 2-Alkyl-Substituted Phenols. Adv. Synth. Catal. 2014, 356, 383-387.


14. Zhang-Pei Chen, Zhi-Shi Ye, Mu-Wang Chen and Yong-Gui Zhou*. Enantioselective Synthesis of Endo-Cyclic Beta-Amino Acids with Two Contiguous Stereocenters via Hydrogenation of 3-Carbalkoxy-2-Substituted Quinolines. Synthesis 2013, 3239-3244.


13. Ran-Ning Guo, Xian-Feng Cai, Lei Shi, Zhi-Shi Ye, Mu-Wang Chen and Yong-Gui Zhou.* An Efficient Route to Chiral N-Heterocycles Bearing C-F Stereogenic Center via Asymmetric Hydrogenation of Fluorinated Isoquinolines. Chem. Commun. 2013, 49, 8537-8539.


12. Xian-Feng Cai, Mu-Wang  Chen, Zhi-Shi  Ye, Ran-Ning  Guo, Lei Shi, Yan-Qin  Li and Yong-Gui  Zhou.* Asymmetric Transfer  Hydrogenation of Aromatic Nitro Compounds, 3-Nitroquinolines: A Facile Access to Cyclic Nitro Compounds with Two Contiguous Stereocenters. Chem. Asian J. 2013, 8, 1381-1385.


11. Zhi-Shi Ye, Ran-Ning Guo, Xian-Feng Cai, Mu-Wang Chen, Lei Shi and Yong-Gui Zhou.* Enantioselective Iridium-Catalyzed Hydrogenation of 1- and 3-Substituted Isoquinolinium Salts. Angew. Chem. Int. Ed. 2013 , 52, 3685-3689.

<Highlighted by Angew. Chem. Int. Ed. 2013, 52, 9616 >


10. Mu-Wang Chen, Liang-Liang Cao, Zhi-Shi Ye, Guo-Fang Jiang and Yong-Gui Zhou.* A Mild Method for Generation of o-Quinone Methide  under the Basic  Condition. The Facile Synthesis of trans-2,3-Dihydrobenzofurans. Chem. Commun. 2013, 49, 1660-1662.


9. Zhi-Shi Ye, Mu-Wang Chen, Qing-An Chen, Lei Shi, Ying  Duan and Yong-Gui Zhou.* Ir-Catalyzed Asymmetric  Hydrogenation of Pyridinium Salts. Angew. Chem. Int. Ed. 2012, 51, 10181-10184.

<Highlighted by Angew. Chem. Int. Ed. 2013, 52, 9616 >

8. Chang-Bin Yu, Kai Gao, Qing-An Chen, Mu-Wang Chen and Yong-Gui Zhou.* Enantioselective Pd-Catalyzed Hydrogenation of Tetrasubstituted Olefins of Cyclic β-(Arylsulfonamido)acrylates. Tetrahedron Lett. 2012, 53, 2560-2563.

7. Mu-Wang Chen, Qing-An Chen, Ying Duan, Zhi-Shi Ye and Yong-Gui Zhou.* Asymmetric Hydrogenolysis of Racemic Tertiary Alcohol, 3-Substituted 3-Hydroxyisoindolin-1-ones. Chem. Commun. 2012, 48, 1698-1700.

6. Ying Duan, Mu-Wang Chen, Qing-An Chen, Chang-Bin Yu  and Yong-Gui Zhou.*  Pd-Catalyzed Asymmetric Hydrogenation of 3-(Toluenesulfonamidoalkyl)indoles. Org. Biomol. Chem. 2012, 10, 1235-1238.

4. Qing-An Chen, Mu-Wang Chen, Chang-Bin Yu, Lei Shi, Duo-Sheng Wang, Yan  Yang and Yong-Gui Zhou.*   Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters  for Asymmetric Hydrogenation of Benzoxazinones. J. Am. Chem. Soc. 2011, 133, 16432-16435.  <Highlighted by Synlett 2012, 1300 >

4. Ying Duan, Mu-Wang Chen, Zhi-Shi Ye, Duo-Sheng Wang, Qing-An Chen, and Yong-Gui Zhou.* An Enantioselective Approach to 2,3-Disubstituted Indolines through  Consecutive Bronsted Acid/Pd-Complex-Promoted Tandem Reactions. Chem. Eur. J. 2011, 17, 7193-7197.

3. Duo-Sheng Wang, Jie Tang, Yong-Gui Zhou,* Mu-Wang Chen, Chang-Bin Yu, Ying Duan and Guo-Fang Jiang.* Dehydration Triggered Asymmetric Hydrogenation of 3-(α-hydroxyalkyl)indoles. Chem. Sci. 2011, 2, 803-806.<Highlighted by SYNFACTS 2011, 624 >

2. Mu-Wang Chen, Ying Duan, Qing-An Chen, Duo-Sheng Wang, Chang-Bin Yu, and Yong-Gui Zhou.* Enantioselective Pd-Catalyzed Hydrogenation of Fluorinated Imines: Facile Access to Chiral Fluorinated Amines. Org. Lett. 2010, 12, 5075-5077.<Highlighted by SYNFACTS 2011, 188>

1. Qing-An Chen, Xiang Dong, Mu-Wang Chen, Duo-Sheng Wang, Yong-Gui Zhou,* and Yu-Xue Li.* Highly Effective and Diastereoselective Synthesis of Axially Chiral Bis-sulfoxide Ligands via Oxidative Aryl Coupling. Org. Lett. 2010, 12, 1928-1931.  <Highlighted by SYNFACTS  2010, 897.>


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