201

陈木旺 副研究员



Mu-Wang Chen(陈木旺)

Associate Professor

Dalian Institute of Chemical Physics,
Chinese Academy of Sciences,
457 Zhongshan Road, Dalian 116023, P. R. China
Tel: 86-411-84379325 (office)
E-mail: chemmuwang@dicp.ac.cn

URL: http://www.researcherid.com/rid/A-9324-2015

 

Educational and Professional Background:

2009.7- present, Associate Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China.
2006.9-2009.7, M.S. in Chemistry, University of Wenzhou.

 

Awards:

 
 
Representative Publications:

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53. Xin-Wei Wang, Xiang Li, Mu-Wang Chen, Bo Wu and Yong-Gui Zhou.* Chiral Phosphoric Acid-Catalyzed Pictet-Spengler Reactions for Synthesis of 5',11'-Dihydrospiro[indoline-3,6'-indolo[3,2‑c]- quinolin]-2-ones Containing Quaternary Stereocenters. J. Org. Chem. 2021, 86, 6897−6906.

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52. Xin-Wei Wang, Mu-Wang Chen, Bo Wu, Baomin Wang, Boshun Wan, and Yong-Gui Zhou.* Chiral Phosphoric Acid-Catalyzed Regioselective Synthesis of Spiro Aminals with Quarternary Stereocenters. Tetrahedron Lett. 2021, 62, 152793.

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51. Zi-Biao Zhao, Xiang Li, Mu-Wang Chen, Bo Wu and Yong-Gui Zhou.*Enantioselective Synthesis of Tetrahydroquinolines via One-pot Cascade Biomimetic Reduction. Chin. J. Chem. 2020, 38, 1691-1695.

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50. Huan-Ping Xie, Bo Wu, Mu-Wang Chen, Chang-Bin Yu, Hong-Wang Li, Xiang Li and Yong-Gui Zhou.* Enantioselective Synthesis of Triarylmethanes Bearing Pyrazole Moiety through Squaramide-catalyzed Addition of Azadienes with Pyrazolin-5-ones. Chin. J. Org. Chem. 2020, 34, 3452-3462.

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49. Zi-Biao Zhao, Xiang Li, Mu-Wang Chen, Zongbao K. Zhao* and Yong-Gui Zhou.* Biomimetic Asymmetric Reduction of Benzoxazinones and Quinoxalinones Using Ureas as Transfer Catalysts. Chem. Commun.2020,56, 7309-7312.

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48. Xiang Li, Zi-Biao Zhao, Mu-Wang Chen, Bo Wu, Chang-Bin Yu* and Yong-Gui Zhou.* Palladium-catalyzed Asymmetric Hydrogenation of 2-Aryl Cyclic Ketones for the Synthesis of trans Cycloalkanols through Dynamic Kinetic Resolution under Acidic Conditions.Chem. Commun.2020,56, 5815-5818.

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47. Chang-Bin Yu, Bo Song, Mu-Wang Chen, Hong-Qiang Shen and Yong-Gui Zhou.* Construction of Multiple-Substituted Chiral Cyclohexanes through Hydrogenative Desymmetrization of 2,2,5-Trisubstituted 1,3-Cyclohexanediones. Org. Lett. 2019, 21, 9401-9404.

46. Xin-Wei Wang, Mu-Wang Chen, Bo Wu, Baomin Wang and Yong-Gui Zhou.* Chiral Phosphoric Acid-Catalyzed Synthesis of Fluorinated 5,6-Dihydroindolo[1,2-c]quinazolines with Quaternary Stereocenters. J. Org. Chem. 2019, 84, 8300-8308.

45. Jie Wang, Zhou-Hao Zhu, Mu-Wang Chen, Qing-An Chen and Yong-Gui Zhou.* Catalytic Biomimetic Asymmetric Reduction of Alkenes and Imines Enabled by Chiral and Regenerable NAD(P)H Models. Angew. Chem. Int. Ed. 2019, 58, 1813-1817.

44. Cong Liu, Hong-Qiang Shen, Mu-Wang Chenand Yong-Gui Zhou.* C2-Symmetric Hindered “Sandwich” Chiral N-Heterocyclic Carbene Precursors and Their Transition Metal Complexes: Expedient Syntheses, Structural Authentication, and Catalytic Properties. Organometallics 2018, 37, 3756-3769.

43. Guang-Shou Feng, Lei Shi,* Fan-Jie Meng, Mu-Wang Chen and Yong-Gui Zhou.* Iridium-Catalyzed Asymmetric Hydrogenation of 4,6-Disubstituted 2-Hydroxypyrimidines. Org. Lett. 2018, 20, 6415-6419.

42. Guang-Shou Feng, Mu-Wang Chen, Lei Shi* and Yong-Gui Zhou.* Facile Synthesis of Chiral Cyclic Ureas through Hydrogenation of 2-Hydroxypyrimidine/Pyrimidin-2(1H)-one Tautomers. Angew. Chem. Int. Ed. 2018, 57, 5853-5857.

41. Bo Song, Mu-Wang Chen and Yong-Gui Zhou.* Synthesis of Chiral Sultams with Two Adjacent Stereocenters via Palladium-catalyzed Dynamic Kinetic Resolution. Org. Chem. Front. 2018, 5, 1113-1117.

40. Shu-Bo Hu, Mu-Wang Chen, Xiao-Yong Zhai and Yong-Gui Zhou.* Synthesis of Tetrahydropyrrolo/ indolo[1,2-a]pyrazines by Enantioselective Hydrogenation of Heterocyclic Imines. Acta Chim. Sinica 2018, 76, 103-106.

39. Yue Ji, Jie Wang, Mu-Wang Chen, Lei Shi* and Yong-Gui Zhou.* Dual Stereocontrol for Enantioselective Hydrogenation of Dihydroisoquinolines Induced by Tuning the Amount of N-Bromosuccinimide. Chin. J. Chem. 2018, 36, 139-142.

38. Mu-Wang Chen, Yue Ji, Jie Wang, Qing-An Chen, Lei Shi and Yong-Gui Zhou.* Asymmetric Hydrogenation of Isoquinolines and Pyridines Using Hydrogen Halide Generated in situ as Activator. Org. Lett. 2017, 19, 4988-4991.

37. Yue Ji, Guang-Shou Feng, Mu-Wang Chen, Lei Shi, Haifeng Du and Yong-Gui Zhou.* Iridium-catalyzed Asymmetric Hydrogenation of Cyclic Iminium Salts. Org. Chem. Front. 2017, 4, 1125-1129.

36. Bo Song, Chang-Bin Yu, Yue Ji, Mu-Wang Chen and Yong-Gui Zhou.* Synthesis of Chiral Sultams via Palladiumcatalyzed Intramolecular Asymmetric Reductive Amination. Chem. Commun. 2017, 53, 1704-1707.

35. Mu-Wang Chen, Bo Wu, Zhang-Pei Chen, Lei Shi and Yong-Gui Zhou.* Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation. Org. Lett. 2016, 18, 4650-4653.

34. Jie Wang, Mu-Wang Chen, Yue Ji, Shu-Bo Hu and Yong-Gui Zhou.* Kinetic Resolution of Axially Chiral 5- or 8-Substituted Quinolines via Asymmetric Transfer Hydrogenation. J. Am. Chem. Soc. 2016, 138, 10413-10416.

33. Zhang-Pei Chen, Shu-Bo Hu, Mu-Wang Chen and Yong-Gui Zhou.* Synthesis of Chiral Fluorinated Hydrazines via Pd-Catalyzed Asymmetric Hydrogenation. Org. Lett. 2016, 18, 2676-2679.

32. Zhong Yan, Bo Wu,                         Mu-Wang Chen and Yong-Gui Zhou.* Enantioselective Synthesis of                         α-Amino Phosphonates                         via Pd-Catalyzed Asymmetric Hydrogenation.                         Org. Lett.                         2016,                         18,692–695.                                

31. Bo Wu, Xiang Gao, Zhong Yan,                         Mu-Wang Chen, and Yong-Gui Zhou.* C-H Oxidation/Michael Addition/Cyclization Cascade for Enantioselective Synthesis of Functionalized 2-Amino-4                         H-chromenes.                         Org. Lett.                         2015,                         17, 6134-6137.                                

30. Xiang Gao, Bo Wu, Wen-Xue Huang, Mu-Wang Chen, and Yong-Gui Zhou.* Enantioselective Palladium-Catalyzed C-H Functionalization of Indoles Using an Axially Chiral 2,2’-Bipyridine Ligand. Angew. Chem. Int. Ed. 2015, 54, 11956-11960.

29. Yue Ji, Lei Shi,* Mu-Wang Chen, Guang-Shou Feng, and Yong-Gui Zhou.* Concise Redox Deracemization of Secondary and Tertiary Amines with a Tetrahydroisoquinoline Core via a Nonenzymatic Process. J. Am. Chem. Soc. 2015, 137, 10496-10499.

28. Zhang-Pei Chen, Mu-Wang Chen, Lei Shi, Chang-Bin Yu and Yong-Gui Zhou.* Pd-catalyzed Asymmetric Hydrogenation of Fluorinated Aromatic Pyrazol-5-ols via Capture of Active Tautomers. Chem. Sci. 2015, 6, 3415-3419.

27. Mu-Wang Chen, Zhi-Shi Ye, Zhang-Pei Chen, Bo Wu and Yong-Gui Zhou.* Enantioselective Synthesis of Trifluoromethyl Substituted Piperidines with Multiple Stereogenic Centers via Hydrogenation of Pyridinium Hydrochlorides. Org. Chem. Front. 2015, 2, 586-589.

26. Wen-Xue Huang, Bo Wu, Xiang Gao, Mu-Wang Chen, Baomin Wang* and Yong-Gui Zhou.* Iridium-Catalyzed Selective Hydrogenation of 3-Hydroxypyridinium Salts: A Facile Synthesis of Piperidin-3-ones. Org. Lett. 2015, 17, 1640-1643.

25. Bo Wu, Xiang Gao, Mu-Wang Chen and Yong-Gui Zhou.* Direct amination of 2-(1-tosylalkyl) phenols with aqueous ammonia: a metal-free synthesis of primary amines.Tetrahedron Lett. 2015, 56, 1135–1137.

24. Yue Ji, Mu-Wang Chen, Lei Shi* and Yong-Gui Zhou.* Highly selective partial dehydrogenation of tetrahydroisoquinolines using modified Pd/C. Chin. J. Catal. 2015, 36, 33-39.

23. Bo Song, Chang-Bin Yu, Wen-Xue Huang, Mu-Wang Chen, and Yong-Gui Zhou.* Formal Palladium-Catalyzed Asymmetric Hydrogenolysis of Racemic N-Sulfonyloxaziridines. Org. Lett. 2015, 17, 190-193.

22. Chang-Bin Yu, Wen-Xue Huang, Lei Shi, Mu-Wang Chen, Bo Wu, and Yong-Gui Zhou.* Asymmetric Hydrogenation via Capture of Active Intermediates Generated from Aza-Pinacol Rearrangement. J. Am. Chem. Soc. 2014, 136, 15837-15840.

21. Bo Wu, Xiang Gao, Mu-Wang Chen, and Yong-Gui Zhou.* A Concise Synthesis of 2-(2-Hydroxy-phenyl)acetonitriles via the o-Quinone Methides Generated from 2-(1-Tosylalkyl)phenols. Chin. J. Chem. 2014, 32, 981-984.

< Cover Article 2014, 32, 10 >

20. Mu-Wang Chen, Xian-Feng Cai, Zhang-Pei Chen, Lei Shi and Yong-Gui Zhou.* Facile construction of three contiguous stereogenic centers via dynamic kinetic resolution in asymmetric transfer hydrogenation of quinolines. Chem. Commun. 2014, 50, 12526-12529.

19. Ying Duan, Lu Li, Mu-Wang Chen, Chang-Bin Yu, Hong-Jun Fan* and Yong-Gui Zhou.* Homogenous Pd-Catalyzed Asymmetric Hydrogenation of Unprotected Indoles: Scope and Mechanistic Studies. J. Am. Chem. Soc. 2014, 136, 7688-7700.


18. Jing Luo, Bo Wu, Mu-Wang Chen, Guo-Fang Jiang* and Yong-Gui Zhou.* The Concise Synthesis of Spiro-Cyclopropane Compounds via the Dearomatization of Indole Derivatives. Org. Lett. 2014, 16, 2578-2581.


17. Xian-Feng Cai, Ran-Ning Guo, Mu-Wang Chen, Lei Shi and Yong-Gui Zhou.* Synthesis of Chiral Exocyclic Amines via Asymmetric Hydrogenation of Aromatic Quinolin-3-amines. Chem. Eur. J. 2014, 20, 7245-7248.


16. Zhang-Pei Chen, Mu-Wang Chen, Ran-Ning Guo and Yong-Gui Zhou.* 4,5-Dihydropyrrolo[1,2-a] quinoxalines: A Tunable and Regenerable Biomimetic Hydrogen Source. Org. Lett. 2014, 16, 1406–1409.


15. Bo Wu, Mu-Wang Chen, Zhi-Shi Ye, Chang-Bin Yu and Yong-Gui Zhou.* A Streamlined Synthesis of 2,3-Dihydrobenzofurans via the ortho-Quinone Methides Generated from 2-Alkyl-Substituted Phenols. Adv. Synth. Catal. 2014, 356, 383-387.


14. Zhang-Pei Chen, Zhi-Shi Ye, Mu-Wang Chen and Yong-Gui Zhou*. Enantioselective Synthesis of Endo-Cyclic Beta-Amino Acids with Two Contiguous Stereocenters via Hydrogenation of 3-Carbalkoxy-2-Substituted Quinolines. Synthesis 2013, 3239-3244.


13. Ran-Ning Guo, Xian-Feng Cai, Lei Shi, Zhi-Shi Ye, Mu-Wang Chen and Yong-Gui Zhou.* An Efficient Route to Chiral N-Heterocycles Bearing C-F Stereogenic Center via Asymmetric Hydrogenation of Fluorinated Isoquinolines. Chem. Commun. 2013, 49, 8537-8539.


12. Xian-Feng Cai, Mu-Wang Chen, Zhi-Shi Ye, Ran-Ning Guo, Lei Shi, Yan-Qin Li and Yong-Gui Zhou.* Asymmetric Transfer Hydrogenation of Aromatic Nitro Compounds, 3-Nitroquinolines: A Facile Access to Cyclic Nitro Compounds with Two Contiguous Stereocenters. Chem. Asian J. 2013, 8, 1381-1385.

11. Zhi-Shi Ye, Ran-Ning Guo, Xian-Feng Cai, Mu-Wang Chen, Lei Shi and Yong-Gui Zhou.* Enantioselective Iridium-Catalyzed Hydrogenation of 1- and 3-Substituted Isoquinolinium Salts. Angew. Chem. Int. Ed. 2013 , 52, 3685-3689.

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10. Mu-Wang Chen, Liang-Liang Cao, Zhi-Shi Ye, Guo-Fang Jiang and Yong-Gui Zhou.* A Mild Method for Generation of o-Quinone Methide under the Basic Condition. The Facile Synthesis of trans-2,3-Dihydrobenzofurans. Chem. Commun. 2013, 49, 1660-1662.

9. Zhi-Shi Ye, Mu-Wang Chen, Qing-An Chen, Lei Shi, Ying Duan and Yong-Gui Zhou.* Ir-Catalyzed Asymmetric Hydrogenation of Pyridinium Salts. Angew. Chem. Int. Ed. 2012, 51, 10181-10184.

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8. Chang-Bin Yu, Kai Gao, Qing-An Chen, Mu-Wang Chen and Yong-Gui Zhou.* Enantioselective Pd-Catalyzed Hydrogenation of Tetrasubstituted Olefins of Cyclic β-(Arylsulfonamido)acrylates. Tetrahedron Lett. 2012, 53, 2560-2563.

7. Mu-Wang Chen, Qing-An Chen, Ying Duan, Zhi-Shi Ye and Yong-Gui Zhou.* Asymmetric Hydrogenolysis of Racemic Tertiary Alcohol, 3-Substituted 3-Hydroxyisoindolin-1-ones. Chem. Commun. 2012, 48, 1698-1700.

6. Ying Duan, Mu-Wang Chen, Qing-An Chen, Chang-Bin Yu and Yong-Gui Zhou.* Pd-Catalyzed Asymmetric Hydrogenation of 3-(Toluenesulfonamidoalkyl)indoles. Org. Biomol. Chem. 2012, 10, 1235-1238.

4. Qing-An Chen, Mu-Wang Chen, Chang-Bin Yu, Lei Shi, Duo-Sheng Wang, Yan Yang and Yong-Gui Zhou.*Biomimetic Asymmetric Hydrogenation: In Situ Regenerable Hantzsch Esters for Asymmetric Hydrogenation of Benzoxazinones. J. Am. Chem. Soc. 2011, 133, 16432-16435. <Highlighted by Synlett 2012, 1300 >

4. Ying Duan, Mu-Wang Chen, Zhi-Shi Ye, Duo-Sheng Wang, Qing-An Chen, and Yong-Gui Zhou.* An Enantioselective Approach to 2,3-Disubstituted Indolines through Consecutive Bronsted Acid/Pd-Complex-Promoted Tandem Reactions. Chem. Eur. J. 2011, 17, 7193-7197.

3. Duo-Sheng Wang, Jie Tang, Yong-Gui Zhou,* Mu-Wang Chen, Chang-Bin Yu, Ying Duan and Guo-Fang Jiang.* Dehydration Triggered Asymmetric Hydrogenation of 3-(α-hydroxyalkyl)indoles. Chem. Sci. 2011, 2, 803-806.<Highlighted by SYNFACTS 2011, 624 >

2. Mu-Wang Chen, Ying Duan, Qing-An Chen, Duo-Sheng Wang, Chang-Bin Yu, and Yong-Gui Zhou.* Enantioselective Pd-Catalyzed Hydrogenation of Fluorinated Imines: Facile Access to Chiral Fluorinated Amines. Org. Lett. 2010, 12, 5075-5077.<Highlighted by SYNFACTS 2011, 188>

1. Qing-An Chen, Xiang Dong, Mu-Wang Chen, Duo-Sheng Wang, Yong-Gui Zhou,* and Yu-Xue Li.* Highly Effective and Diastereoselective Synthesis of Axially Chiral Bis-sulfoxide Ligands via Oxidative Aryl Coupling. Org. Lett. 2010, 12, 1928-1931. <Highlighted by SYNFACTS 2010, 897.>